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[Potential marker of the pharmacodynamic effect of high doses of methotrexate--homocysteine].

Authors
  • Strizhevskaya, A M
  • Senzhapova, E R
  • Dzamraev, A Z
  • Baykova, V N
Type
Published Article
Journal
Patologicheskaia fiziologiia i èksperimental'naia terapiia
Publication Date
Jan 01, 2014
Issue
2
Pages
40–44
Identifiers
PMID: 25318162
Source
Medline
License
Unknown

Abstract

High-dose methotrexate blocks the metabolic pathways of conversion of homocysteine to methionine. As a result, homocysteine (hcy) accumulates in the blood. The aim of this study was to determine the relationship between changes in concentrations of hcy, mtx, and other criteria of toxicity in the key hours of therapeutic drug monitoring of mtx, as well as identifying the possibility of using hcy as a marker of toxicity and effectiveness of high-dose mtx therapy. The study includes data on 246 children with osteosarcoma of different localisation.

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