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Potential of Chemically Synthesized Oligosaccharides To Define the Carbohydrate Moieties of the Fungal Cell Wall Responsible for the Human Immune Response, Using Aspergillus fumigatus Galactomannan as a Model

Authors
  • Wong, Sarah Sze Wah
  • Krylov, Vadim
  • Argunov, Dmitry
  • Karelin, Alexander
  • Bouchara, Jean-Phillipe
  • Fontaine, Thierry
  • Latge, Jean-Paul
  • Nifantiev, Nikolay
Publication Date
Feb 26, 2020
Source
HAL-ENAC
Keywords
Language
English
License
Unknown
External links

Abstract

Methodologies to identify epitopes or ligands of the fungal cell wall polysaccharides influencing the immune response of human pathogens have to date been imperfect. Using the galactomannan (GM) of Aspergillus fumigatus as a model, we have shown that synthetic oligosaccharides of distinct structures representing key fragments of cell wall polysaccharides are the most precise tools to study the serological and immunomodulatory properties of a fungal polysaccharide.

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