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Potential Application of the CRISPR/Cas9 System against Herpesvirus Infections

Authors
  • Chen, Yuan-Chuan
  • Sheng, Jingxue
  • Trang, Phong
  • Liu, Fenyong
Publication Date
May 29, 2018
Source
MDPI
Keywords
Language
English
License
Green
External links

Abstract

s sarcoma-associated herpesvirus. CRISPR/Cas9-directed mutagenesis can introduce similar types of mutations to the viral genome as can bacterial artificial chromosome recombination engineering, which maintains and reconstitutes the viral genome successfully. The cleavage mediated by CRISPR/Cas9 enables the manipulation of disease-associated viral strains with unprecedented efficiency and precision. Additionally, current therapies for herpesvirus productive and latent infections are limited in efficacy and cannot eradicate viruses. CRISPR/Cas9 is potentially adapted for antiviral treatment by specifically targeting viral genomes during latent infections. This review, which focuses on recently published progress, suggests that the CRISPR/Cas9 system is not only a useful tool for basic virology research, but also a promising strategy for the control and prevention of herpesvirus latent infections.

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