Affordable Access

Potential antineoplastics I: substituted 3,5-dioxo-and 3-thioxo-5-oxo-2,3,4,5-tetrahydro-1,2,4-triazines.

Authors
  • Shams el-Dine, S A
  • Soliman, F S
  • Labouta, I M
Type
Published Article
Journal
Journal of pharmaceutical sciences
Publication Date
Feb 01, 1979
Volume
68
Issue
2
Pages
243–245
Identifiers
PMID: 423100
Source
Medline
License
Unknown

Abstract

The synthesis of some 6-substituted 3,5-dioxo- and 3-thioxo-5-oxo-2,3,4,5-tetrahydro-1,2,4-triazines for possible antineoplastic activity is reported. The assigned structures were substantiated by IR, NMR, and mass spectral studies of representative members of the series. Four compounds were tested against P-388 lymphocytic leukemia and were inactive.

Report this publication

Statistics

Seen <100 times