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A potent antiangiogenic factor, endostatin prevents the development of asthma in a murine model.

Authors
  • Suzaki, Yasue
  • Hamada, Kaoru
  • Sho, Masayuki
  • Ito, Toshihiro
  • Miyamoto, Kenichi
  • Akashi, Satoru
  • Kashizuka, Hisanori
  • Ikeda, Naoya
  • Nakajima, Yoshiyuki
  • Iwase, Michiko
  • Homma, Ikuo
  • Kobzik, Lester
  • Kimura, Hiroshi
Type
Published Article
Journal
Journal of Allergy and Clinical Immunology
Publisher
Elsevier
Publication Date
Dec 01, 2005
Volume
116
Issue
6
Pages
1220–1227
Identifiers
PMID: 16337449
Source
Medline
License
Unknown

Abstract

These data demonstrate for the first time that recombinant endostatin can prevent the development of asthma features in a mouse model and suggest that this class of agents merits further study as novel therapeutics for asthma.

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