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Potassium-induced release of tritiated histamine from rat brain tissue slices.

Authors
Type
Published Article
Journal
European Journal of Pharmacology
0014-2999
Publisher
Elsevier
Publication Date
Volume
35
Issue
1
Pages
203–206
Identifiers
PMID: 56272
Source
Medline
License
Unknown

Abstract

The release of exogenous histamine was studied by superfusing brain slices following incubation with the radiolabeled amine. Histamine was released in a calcium-dependent way by 40 mM potassium. This release was high in hypothalamus and striatum and low in hippocampus and cortex. Compound 48/80, a mast cell histamine releasing agent, also induced histamine release, but only from hypothalamic tissue slices. It is suggested that the potassium-induced release of accumulated exogenous histamine is mainly from glial cells.

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