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Posttranscription Initiation Control of Gene Expression Mediated by Bacterial RNA-Binding Proteins

Authors
  • Babitzke, Paul
  • Lai, Ying-Jung
  • Renda, Andrew J.
  • Romeo, Tony
Type
Published Article
Journal
Annual Review of Microbiology
Publisher
Annual Reviews
Publication Date
Sep 08, 2019
Volume
73
Pages
43–67
Identifiers
DOI: 10.1146/annurev-micro-020518-115907
Source
Annual Reviews
Keywords
License
Yellow

Abstract

RNA-binding proteins play vital roles in regulating gene expression and cellular physiology in all organisms. Bacterial RNA-binding proteins can regulate transcription termination via attenuation or antitermination mechanisms, while others can repress or activate translation initiation by affecting ribosome binding. The RNA targets for these proteins include short repeated sequences, longer single-stranded sequences, RNA secondary or tertiary structure, and a combination of these features. The activity of these proteins can be influenced by binding of metabolites, small RNAs, or other proteins, as well as by phosphorylation events. Some of these proteins regulate specific genes, while others function as global regulators. As the regulatory mechanisms, components, targets, and signaling circuitry surrounding RNA-binding proteins have become better understood, in part through rapid advances provided by systems approaches, a sense of the true nature of biological complexity is becoming apparent, which we attempt to capture for the reader of this review.

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