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Postoperative sensitivity in posterior resin composite restorations with prior application of a glutaraldehyde-based desensitizing solution: a randomized clinical trial.

  • de Oliveira, Isabelle Lins Macêdo1
  • Hanzen, Taíse Alessandra2
  • de Paula, Alexandra Mara2
  • Perdigão, Jorge3
  • Montes, Marcos Antonio Japiassú Resende1
  • Loguercio, Alessandro Dourado2
  • Monteiro, Gabriela Queiroz de Melo1
  • 1 Dental School, Universidade de Pernambuco, Pernambuco, PE, Brazil; Instituto de Tecnologia de Pernambuco - ITEP/ Block B 1st floor. Av. Prof. Luis Freire, 700 - Cidade Universitária, Recife-PE, Brazil; Zip code: 50740-540. , (Brazil)
  • 2 Department of Restorative Dentistry, School of Dentistry, State University of Ponta Grossa, Ponta Grossa, PR, Brazil; Campus Uvaranas - Bloco M - 52B 2° Piso, General Carlos Cavalcanti Avenue, 4748 - Ponta Grossa - PR; Zip code 84030-900. , (Brazil)
  • 3 Universidade Católica Portuguesa, Centre for Interdisciplinary Research in Health, Faculty of Dental Medicine, Estrada da Circunvalação, 3504-505 Viseu, Portugal; Department of Restorative Sciences, School of Dentistry, University of Minnesota, 515 Delaware St. SE, 8-450 Moos Tower, Minneapolis, MN, 55455. , (Portugal)
Published Article
Journal of dentistry
Publication Date
Dec 05, 2021
DOI: 10.1016/j.jdent.2021.103918
PMID: 34879245


To evaluate the effect of a glutaraldehyde-based desensitizer on the postoperative sensitivity (POS) in posterior resin composite restorations up to 12 months using a universal adhesive (Tetric N-Bond Universal) with selective enamel etching (SE) or an etch-and-rinse (ER) strategy. Class I and class II resin composite restorations (n=220) at least 3 mm deep were inserted in 55 subjects. The universal adhesive was applied using the SE (self-etch strategy on dentin with selective enamel etching) or the ER strategy, with or without prior application of a glutaraldehyde-based desensitizer (Gluma Desensitizer - GL) to form groups XXGL and ERGL. A bulk-fill resin composite (Tetric N-Ceram Bulk Fill) was used for all restorations. Spontaneous POS was assessed 7 days after the restorative procedure using the Visual Analog Scale (VAS) and the Numeric Rating Scale (NRS). After 7, 14, and 30 days of completing each restoration, the subjects were reassessed to evaluate POS caused by stimulation with an air blast, horizontal and vertical percussion. In addition, marginal discoloration, marginal adaptation, fracture, and recurrence of caries were evaluated using the FDI (World Dental Federation) criteria after 7 days and at 12 months. No significant spontaneous or stimuli-induced POS was observed when restorations with or without GL were compared (p>0.05). A higher risk of spontaneous POS was observed within 7 days (40.0%; 95% CI 28.1 to 53.1), without statistically significant differences among groups. None of the participants reported POS at 12 months, however five restorations were considered clinically unsatisfactory (p > 0.05). The previous application of GL did not significantly reduce spontaneous or stimuli-induced POS in posterior resin composite restorations at any time, regardless of the adhesive strategy used. The use of a glutaraldehyde-based desensitizing agent did not generate lower incidence of postoperative sensitivity in resin composite posterior restorations. Copyright © 2021. Published by Elsevier Ltd.

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