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Postoperative intraperitoneal 5-fluoro-2'-deoxyuridine added to chemoradiation in patients curatively resected (R0) for locally advanced gastric and gastroesophageal junction adenocarcinoma.

Authors
  • Cohen, Deirdre J
  • Newman, Elliot
  • Iqbal, Syma
  • Chang, Richard Y
  • Potmesil, Milan
  • Ryan, Theresa
  • Donahue, Bernadine
  • Chandra, Anurag
  • Liu, Mengling
  • Utate, Minerva
  • Hiotis, Spiros
  • Pachter, Leon H
  • Hochster, Howard
  • Muggia, Franco
Type
Published Article
Journal
Annals of Surgical Oncology
Publisher
Springer - Society of Surgical Oncology
Publication Date
Feb 01, 2012
Volume
19
Issue
2
Pages
478–485
Identifiers
DOI: 10.1245/s10434-011-1940-8
PMID: 21769462
Source
Medline
License
Unknown

Abstract

IP FUDR before chemoradiation after R(0) gastric cancer resection is well tolerated without compromising completion of postoperative adjuvant treatment. Larger randomized trials studying IP FUDR as part of gastric cancer multidisciplinary treatment are needed to prove efficacy in reducing regional recurrence and improving survival.

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