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Postnatal germ cell development during mini-puberty in the mouse does not require androgen receptor: implications for managing cryptorchidism.

Authors
  • Li, Ruili1
  • Vannitamby, Amanda2
  • Meijer, Jorien3
  • Southwell, Bridget4
  • Hutson, John5
  • 1 Douglas Stephens Surgical Research Laboratory, Murdoch Children's Research Institute, Parkville, Victoria, Australia; Department of Pediatrics, University of Melbourne, Parkville, Victoria, Australia. Electronic address: [email protected] , (Australia)
  • 2 Douglas Stephens Surgical Research Laboratory, Murdoch Children's Research Institute, Parkville, Victoria, Australia. , (Australia)
  • 3 Medical School, University of Groningen, Groningen, The Netherlands. , (Netherlands)
  • 4 Douglas Stephens Surgical Research Laboratory, Murdoch Children's Research Institute, Parkville, Victoria, Australia; Department of Pediatrics, University of Melbourne, Parkville, Victoria, Australia. , (Australia)
  • 5 Douglas Stephens Surgical Research Laboratory, Murdoch Children's Research Institute, Parkville, Victoria, Australia; Department of Pediatrics, University of Melbourne, Parkville, Victoria, Australia; Urology Department, Royal Children's Hospital, Parkville, Victoria, Australia. Electronic address: [email protected] , (Australia)
Type
Published Article
Journal
The Journal of urology
Publication Date
April 2015
Volume
193
Issue
4
Pages
1361–1367
Identifiers
DOI: 10.1016/j.juro.2014.10.024
PMID: 25315959
Source
Medline
Keywords
License
Unknown

Abstract

Androgen receptors are not required for gonocyte migration from the center of the testicular tubules to the basement membrane and transformation into spermatogonia stem cells up to day 10 in androgen receptor knockout mice. Identifying nonandrogenic factors might improve the fertility potential of boys with undescended testis who are undergoing orchiopexy.

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