Affordable Access

The possible role of tyrosinase in malignant growth.

Authors
  • Rubin, D M
  • Rubin, E J
Type
Published Article
Journal
Medical Hypotheses
Publisher
Elsevier
Publication Date
Apr 01, 1983
Volume
10
Issue
4
Pages
469–471
Identifiers
PMID: 6410161
Source
Medline
License
Unknown

Abstract

The sera of patients who suffer from melanoma and mammary carcinoma show higher tyrosinase activity than normal sera. The enzyme tyrosinase oxidizes tyrosine to DOPA and also catalizes the oxidation of DOPA to Melanin. The catalytic oxidation might also occur in tyrosine while it is conjugated to other amino acids in a polypeptide or a protein molecule. It is theorized here that gamma globulins and interferons are vulnerable to this catalytic oxidation which eventually denaturates them and diminishes their immunological properties.

Report this publication

Statistics

Seen <100 times