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Possible role of proteases in preconditioning of brain cells to pathological conditions

Authors
  • Yakovlev, A. A.1
  • Gulyaeva, N. V.1
  • 1 Russian Academy of Sciences, Institute of Higher Nervous Activity and Neurophysiology, Moscow, 117485, Russia , Moscow (Russia)
Type
Published Article
Journal
Biochemistry (Moscow)
Publisher
Pleiades Publishing
Publication Date
Feb 18, 2015
Volume
80
Issue
2
Pages
163–171
Identifiers
DOI: 10.1134/S0006297915020030
Source
Springer Nature
Keywords
License
Yellow

Abstract

Preconditioning (PC) is one of the most effective strategies to reduce the severity of cell damage, in particular of nervous tissue cells. Although PC mechanisms are studied insufficiently, it is clear that proteases are involved in them, but their role has yet been not studied in detail. In this work, some mechanisms of a potential recruiting of proteases in PC are considered. Our attention is mainly focused on the protease families of caspases and cathepsins and on protease receptors. We present evidence that just these proteins are involved in the PC of brain cells. A hypothesis is proposed that secreted cathepsin B is involved in the realization of PC through activation of PAR2 receptor.

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