Affordable Access

Possible mechanisms of abnormal norepinephrine sensitivity and reactivity of resistance vessels and the development of hypertension in spontaneously hypertensive rats. A hypothesis.

Authors
  • Kishi, K
  • Inoue, T
Type
Published Article
Journal
American journal of hypertension
Publication Date
Aug 01, 1990
Volume
3
Issue
8 Pt 2
Identifiers
PMID: 2222968
Source
Medline
License
Unknown

Abstract

This study examined structural and functional changes of mesenteric resistance vessels in early, developing, and established stages of hypertension development in spontaneously hypertensive rats in an attempt to identify possible mechanisms of the development and maintenance of hypertension. Our results suggest that the development of hypertension in spontaneously hypertensive rats may be caused by genetic structural and functional abnormalities of resistance vessels. Both abnormalities may be caused by hyperreactivity to norepinephrine through an altered signal transduction process, including the regulation of protein kinase C in smooth muscle cells of resistance vessels in spontaneously hypertensive rats.

Report this publication

Statistics

Seen <100 times