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Possible involvement of minor lysophospholipids in the increase in plasma lysophosphatidic acid in acute coronary syndrome.

Authors
  • Kurano, Makoto
  • Suzuki, Akiko
  • Inoue, Asuka
  • Tokuhara, Yasunori
  • Kano, Kuniyuki
  • Matsumoto, Hirotaka
  • Igarashi, Koji
  • Ohkawa, Ryunosuke
  • Nakamura, Kazuhiro
  • Dohi, Tomotaka
  • Miyauchi, Katsumi
  • Daida, Hiroyuki
  • Tsukamoto, Kazuhisa
  • Ikeda, Hitoshi
  • Aoki, Junken
  • Yatomi, Yutaka
Type
Published Article
Journal
Arteriosclerosis Thrombosis and Vascular Biology
Publisher
Ovid Technologies Wolters Kluwer -American Heart Association
Publication Date
Feb 01, 2015
Volume
35
Issue
2
Pages
463–470
Identifiers
DOI: 10.1161/ATVBAHA.114.304748
PMID: 25425621
Source
Medline
Keywords
License
Unknown

Abstract

Specific LPA species, especially long-chain unsaturated LPA, were elevated in ACS patients, along with the corresponding minor lysophospholipids. The elevation of these LPA species might be mainly caused by presently unidentified LPA-producing pathway(s). Minor lysophospholipids might be involved in the generation of LPA, especially 22:6 LPA, and in the pathogenesis of ACS.

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