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[Possibility of developing tolerance to the anti-anginal effect of isosorbide dinitrate and verapamil].

Authors
  • Metelitsa, V I
  • Shakarova, S Sh
  • Martsevich, S Iu
  • Vygodin, V A
  • Strel'tsov, A A
Type
Published Article
Journal
Kardiologiia
Publication Date
Jan 01, 1985
Volume
25
Issue
1
Pages
63–67
Identifiers
PMID: 3920428
Source
Medline
License
Unknown

Abstract

Using exercise tests in 22 patients with stable angina of effort, the authors studied the possibility of the development of tolerance to the antianginal effect of isosorbide dinitrate (ID) and verapamil (VP). Within 6-12 weeks of the regular intake of ID, 5 (26%) patients developed complete tolerance, 6 (32%) partial tolerance to the drug. In 8 (42%) patients the effect of ID remained stable. A six-week administration of VP was accompanied by no signs of tolerance to the drug even in the patients who showed tolerance to ID.

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