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Positron emission tomographic studies of changes in cerebral blood flow and oxygen metabolism in neuroleptic malignant syndrome

Authors
  • De Reuck, Jacques
  • Van Aken, Jozef
  • Van Landegem, William
  • Colardyn, Francis
Publication Date
Jan 01, 1991
Identifiers
DOI: 10.1159/000116625
OAI: oai:archive.ugent.be:225647
Source
Ghent University Institutional Archive
Keywords
Language
English
License
Unknown
External links

Abstract

Three patients with neuroleptic malignant syndrome were studied by positron emission tomography (PET), using the steady-state technique with C15O2 and (O2.)-O-15. In 2 patients the PET examination was repeated after resolution of the syndrome. In 2 patients, under treatment with bromocriptine, high blood flow and oxygen metabolism were demonstrated in the striatum, cerebellum and occipital cerebral cortex during the neuroleptic malignant phase, showing that not only the dopaminergic system is disturbed but also other neurotransmitter systems are involved. In the 3rd case the PET scan findings were not as conclusive.

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