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Positive state observer for the automatic control of the depth of anesthesia-Clinical results.

Authors
  • Nogueira, Filipa N1
  • Mendonça, T2
  • Rocha, P3
  • 1 CTAC-The Center for Territory, Environment and Construction, School of Engineering of University of Minho, 4800-048 Guimarães, Portugal. Electronic address: [email protected] , (Portugal)
  • 2 Faculdade de Ciências da Universidade do Porto, 4169-007 Porto, Portugal; SYSTEC-Research Center for Systems & Technologies, Porto, Portugal. , (Portugal)
  • 3 SYSTEC-Research Center for Systems & Technologies, Porto, Portugal; Faculdade de Engenharia da Universidade do Porto, 4200-465, Porto, Portugal. , (Portugal)
Type
Published Article
Journal
Computer methods and programs in biomedicine
Publication Date
Apr 01, 2019
Volume
171
Pages
99–108
Identifiers
DOI: 10.1016/j.cmpb.2016.08.019
PMID: 27647647
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The depth of anesthesia (DoA) is a crucial feature in general anesthesia. Nowadays the DoA is usually evaluated by the bispectral index (BIS). According to the surgical procedure, different reference levels for the BIS may be clinically required. This can be achieved by the simultaneous administration of an analgesic (e.g. remifentanil) and an hypnotic (eg propofol). As a contribution to the effort of automating the processes of drug delivery in general anesthesia, in this paper, a positive state observer is designed for the implementation of a control scheme proposed for the automatic administration of propofol and of remifentanil, in order to track a desired level for the BIS. It is proved and illustrated by simulations that the controller-observer scheme has a very good performance. This scheme was implemented, tested and evaluated both by means of simulations and for a set of patients during surgical procedures. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

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