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Positive predictive value of CD200 positivity in the differential diagnosis of chronic lymphocytic leukemia.

Authors
  • Sorigue, Marc1
  • Magnano, Laura2
  • Miljkovic, Milos D3
  • Nieto-Moragas, Javier4
  • Santos-Gomez, Mireia1
  • Villamor, Neus2
  • Junca, Jordi1
  • Morales-Indiano, Cristian5
  • 1 Hematology Laboratory, ICO-Hospital Germans Trias i Pujol. IJC, Universitat Autònoma de Barcelona, Badalona, Spain. , (Spain)
  • 2 Hematopathology Unit, Department of Pathology, Hospital Clinic de Barcelona, Barcelona, Spain. , (Spain)
  • 3 Lymphoid Malignancies Branch, National Cancer Institute, Bethesda, Maryland. , (Mali)
  • 4 Clinical Laboratory, Hospital Dr Josep Trueta, Girona, Spain. , (Spain)
  • 5 Clinical Laboratory ICS-Metropolitana Nord, Core-hematology Department, Hospital Germans Trias i Pujol, Badalona, Spain. , (Spain)
Type
Published Article
Journal
Cytometry. Part B, Clinical cytometry
Publication Date
Sep 01, 2020
Volume
98
Issue
5
Pages
441–448
Identifiers
DOI: 10.1002/cyto.b.21849
PMID: 31692239
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The role of CD200 in the differential diagnosis of chronic lymphocytic leukemia (CLL) and classical mantle cell lymphoma (MCL) is well established. Its role in the differential diagnosis of CLL and other lymphoproliferative disorders (LPD) is less clear, in particular its positive predictive value (PPV). We conducted a systematic review of the use of CD200 in the differential diagnosis of CLL, MCL, and other predominantly leukemic, typically CD103-negative LPD. With the results, we then derived a curve to determine the PPV based on the prevalence of the disorders included in the differential diagnosis. Of 43 publications screened, 27 were included in the systematic review (5,764 patients). The median CD200 positivity rate in all studies and the percentage of CD200-positive (pooled) patients was 100% and 95% (3,061/3,208) in CLL, 4 and 8% (86/1112) in MCL and 56 and 62% (425/689) in other LPD. CD200 is suboptimal for the differential diagnosis of CLL and disorders other than nodal MCL. © 2019 International Clinical Cytometry Society.

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