Affordable Access

Positive and negative symptoms in families with schizophrenia.

Authors
  • Bassett, A S1
  • Collins, E J
  • Nuttall, S E
  • Honer, W G
  • 1 Department of Psychiatry, University of Toronto, Ont., Canada. , (Canada)
Type
Published Article
Journal
Schizophrenia Research
Publisher
Elsevier
Publication Date
Dec 01, 1993
Volume
11
Issue
1
Pages
9–19
Identifiers
PMID: 8297809
Source
Medline
License
Unknown

Abstract

Positive and negative symptoms are measurable characteristics that may represent core features of schizophrenia and offer a quantitative approach for studying the genetics of schizophrenia and related disorders. The Positive and Negative Syndrome Scale (PANSS) was used to assess 72 members of five families segregating schizophrenia. The study confirmed high internal reliability of PANSS scales in this sample with diverse lifetime diagnoses. Gender but not alcoholism affected scores. Schizophrenia/schizoaffective and schizophrenia spectrum disorder groups had higher mean scores for the positive and negative scales than other lifetime diagnostic groups, consistent with genetic transmission of these symptoms. Positive and negative symptom patterns did not subtype families. The results support the validity of positive and negative symptom measures as independent dimensions in familial schizophrenia.

Report this publication

Statistics

Seen <100 times