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Posaconazole Therapy of Disseminated Phaeohyphomycosis in a Murine Model

Authors
  • John R. Graybill
  • Laura K. Najvar
  • Elizabeth Johnson
  • Rosie Bocanegra
  • David Loebenberg
Publisher
American Society for Microbiology
Publication Date
Jun 01, 2004
Source
PMC
Keywords
License
Unknown

Abstract

Immunocompetent (nu/+) and athymic (nu/nu) BALB/c mice were infected intravenously with Wangiella dermatitidis and treated with posaconazole. Posaconazole reduced the counts in tissues and prolonged survival. Of particular interest, posaconazole reduced the counts of this neurotropic pathogen in the brain.

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