Affordable Access

deepdyve-link deepdyve-link
Publisher Website

Porin involvement in cephalosporin and carbapenem resistance of Burkholderia pseudomallei.

Authors
  • 1
  • 1
  • 2
  • 1
  • 1 Biochemistry-Electrochemistry Research Unit, Schools of Chemistry and Biochemistry, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima, Thailand. , (Thailand)
  • 2 School of Engineering and Science, Jacobs University, Bremen, Germany. , (Germany)
Type
Published Article
Journal
PLoS ONE
1932-6203
Publisher
Public Library of Science
Publication Date
Volume
9
Issue
5
Identifiers
DOI: 10.1371/journal.pone.0095918
PMID: 24788109
Source
Medline
License
Unknown

Abstract

Our results, from both in vivo and in vitro studies, demonstrate that membrane permeability associated with BpsOmp38 expression correlates well with the antimicrobial susceptibility of the virulent bacterium B. pseudomallei, especially to carbapenems and cephalosporins. In addition, substitution of the residue Tyr119 affects the permeability of the BpsOmp38 channel to neutral sugars and antimicrobial agents.

Statistics

Seen <100 times