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Pore helix domain is critical to camphor sensitivity of transient receptor potential vanilloid 1 channel.

Authors
  • Marsakova, Lenka
  • Touska, Filip
  • Krusek, Jan
  • Vlachova, Viktorie
Type
Published Article
Journal
Anesthesiology
Publication Date
Apr 01, 2012
Volume
116
Issue
4
Pages
903–917
Identifiers
DOI: 10.1097/ALN.0b013e318249cf62
PMID: 22314297
Source
Medline
License
Unknown

Abstract

The findings of this study provide novel insights into the structural basis for the modulation of TRPV1 channel by camphor and may provide an explanation for the mechanism by which camphor modulates thermal sensation in vivo.

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