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Pore change during degradation of octreotide acetate-loaded PLGA microspheres: The effect of polymer blends.

Authors
  • Wang, Tengteng1
  • Xue, Peng2
  • Wang, Aiping1
  • Yin, Miaomiao1
  • Han, Junping1
  • Tang, Shengnan1
  • Liang, Rongcai3
  • 1 School of Pharmacy, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Yantai University, Yantai, Shandong Province, People's Republic of China. , (China)
  • 2 State Key Laboratory of Long-Acting and Targeting Drug Delivery System, Shandong Luye Pharmaceutical Co., Ltd., Yantai, Shandong Province, People's Republic of China. , (China)
  • 3 School of Pharmacy, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Yantai University, Yantai, Shandong Province, People's Republic of China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
Publication Date
Jul 11, 2019
Volume
138
Pages
104990–104990
Identifiers
DOI: 10.1016/j.ejps.2019.104990
PMID: 31302216
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The purpose of this study was to solve the plateau phase (the stage in which the drug in the microsphere undergoes a slow release or almost no release after initial release) problem by understanding the effect of polymer blends on the internal pore changes of the microspheres. This study used PLGA 5050 4H (F-1), PLGA 5050 1A: PLGA 5050 4H = 3:7 (F-2) and PLGA 7525 1A: PLGA 5050 4H = 3:7 (F-3) as a carrier, respectively. Microspheres (MS) were obtained by O/W emulsion solvent evaporation technique and characterized by scanning electron microscopy (SEM), particle size, drug loading, fluorescence characteristics, and in vitro and in vivo release. Accelerated tests in vitro showed that the size and number of core pores significantly affected drug release in the first and second phases. After intramuscular administration, F-2 and F-3 showed effective blood concentration levels and their bioavailability was higher than that of the RLD (Sandostatin Lar). In general, our data indicate that pore formation is unevenly distributed throughout PLGA MS prepared using polymer blends, and the use of polymer blends is instructive for the development of sustained smooth release microspheres. Therefore, the octreotide MS described in this study has a good clinical application potential for the treatment of acromegaly. Copyright © 2019 Elsevier B.V. All rights reserved.

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