Affordable Access

Access to the full text

Porcine sialoadhesin suppresses type I interferon production to support porcine reproductive and respiratory syndrome virus infection

Authors
  • Liu, Yingqi1
  • Li, Rui1
  • Qiao, Songlin1
  • Chen, Xin-xin1
  • Deng, Ruiguang1
  • Zhang, Gaiping1, 2
  • 1 Henan Academy of Agricultural Sciences, Zhengzhou, Henan, 450002, China , Zhengzhou (China)
  • 2 Henan Agricultural University, Zhengzhou, Henan, 450002, China , Zhengzhou (China)
Type
Published Article
Journal
Veterinary Research
Publisher
BioMed Central
Publication Date
Feb 24, 2020
Volume
51
Issue
1
Identifiers
DOI: 10.1186/s13567-020-00743-7
Source
Springer Nature
License
Green

Abstract

Porcine reproductive and respiratory syndrome virus (PRRSV) is a significant threat to the global swine industry. Porcine sialoadhesin (poSn) has been previously shown to mediate PRRSV attachment and internalization. In the current study, we report its unidentified role in antagonism of type I interferon (IFN) production during PRRSV infection. We determined that poSn facilitated PRRSV infection via inhibition of type I IFN transcription. Mechanistically, poSn interacted with a 12 kDa DNAX-activation protein (DAP12), which was dependent on residues 51–57 within DAP12 transmembrane domain (TMD). PRRSV exploited the poSn-DAP12 pathway to attenuate activation of nuclear factor-kappa B (NF-κB). More importantly, the poSn-DAP12 pathway was involved in inhibiting poly (I:C)-triggered IFN production. All these results reveal a novel role of poSn in suppressing host antiviral responses, which deepens our understanding of PRRSV pathogenesis.

Report this publication

Statistics

Seen <100 times