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The porcine circovirus type 1 capsid gene promoter improves antigen expression and immunogenicity in a HIV-1 plasmid vaccine.

Authors
  • Tanzer, Fiona L1
  • Shephard, Enid G
  • Palmer, Kenneth E
  • Burger, Marieta
  • Williamson, Anna-Lise
  • Rybicki, Edward P
  • 1 Department of Molecular and Cell Biology, Faculty of Science, University of Cape Town, Rondebosch, Cape Town, 7701 South Africa. , (South Africa)
Type
Published Article
Journal
Virology Journal
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Feb 07, 2011
Volume
8
Pages
51–51
Identifiers
DOI: 10.1186/1743-422X-8-51
PMID: 21299896
Source
Medline
License
Unknown

Abstract

We identified a novel PCV-1 genome-derived enhancer sequence that significantly increased antigen expression from plasmids in in vitro assays, and improved immunogenicity in mice of the HIV-1 subtype C vaccine plasmid, pTHgrttnC. This should allow significant dose sparing of, or increased responses to, this and other plasmid-based vaccines. We also report investigations of the potential of other circovirus-derived sequences to be similarly used.

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