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Population pharmacokinetics of amikacin at birth and interindividual variability in renal maturation.

Authors
Type
Published Article
Journal
European Journal of Clinical Pharmacology
0031-6970
Publisher
Springer-Verlag
Publication Date
Volume
57
Issue
6-7
Pages
499–504
Identifiers
PMID: 11699615
Source
Medline

Abstract

These results show that amikacin elimination and the volume of distribution are dependent upon GA, and that differential renal maturation in neonates is responsible for the wider PK interindividual variability with high GA. Dosage regimens of amikacin and other aminoglycosides should be revised in newborns with high GA. Bayesian adaptive control of therapeutics might be particularly indicated to obtain efficacy for each neonate as early as the first dose.

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