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Population pharmacokinetic modelling of NS2330 (tesofensine) and its major metabolite in patients with Alzheimer's disease.

Authors
  • Lehr, Thorsten
  • Staab, Alexander
  • Tillmann, Christiane
  • Trommeshauser, Dirk
  • Raschig, Andreas
  • Schaefer, Hans Guenter
  • Kloft, Charlotte
Type
Published Article
Journal
British journal of clinical pharmacology
Publication Date
Jul 01, 2007
Volume
64
Issue
1
Pages
36–48
Identifiers
PMID: 17324246
Source
Medline
License
Unknown

Abstract

A descriptive, robust and predictive model for NS2330 and its M1 metabolite was developed. Important covariates influencing pharmacokinetics were identified, which might guide the further development of NS2330 and optimize its long-term use in the treatment of Alzheimer's disease.

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