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Population-based hospitalization burden of influenza a virus subtypes and antigenic drift variants in children in Hong Kong (2004-2011).

Authors
  • 1
  • 2
  • 3
  • 1
  • 4
  • 5
  • 5
  • 1
  • 6
  • 1 Department of Pediatrics & Adolescent Medicine, The University of Hong Kong, Pokfulam, Hong Kong. , (Hong Kong SAR China)
  • 2 Public Health Laboratory Services Branch, Centre for Health Protection, Department of Health, Kowloon, Hong Kong. , (Hong Kong SAR China)
  • 3 Department of Microbiology, The University of Hong Kong, Pokfulam, Hong Kong. , (Hong Kong SAR China)
  • 4 Department of Pediatrics and Adolescent Medicine, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong. , (Hong Kong SAR China)
  • 5 Division of Epidemiology and Biostatistics, School of Public Health, The University of Hong Kong, Pokfulam, Hong Kong. , (Hong Kong SAR China)
  • 6 Centre of Influenza Research, School of Public Health, The University of Hong Kong, Pokfulam, Hong Kong. , (Hong Kong SAR China)
Type
Published Article
Journal
PLoS ONE
1932-6203
Publisher
Public Library of Science
Publication Date
Volume
9
Issue
4
Identifiers
DOI: 10.1371/journal.pone.0092914
PMID: 24786780
Source
Medline
License
Unknown

Abstract

We documented a consistently high pediatric hospitalization burden of influenza A. Knowledge of antigenic changes and their proportion of circulation aids in the interpretation of impact of the subtypes. Year-to-year variation in hospitalization rates in young infants appeared to correlate with antigenic variation, lending support to the role of protection from maternal antibodies.

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