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Poor diagnostic accuracy of commercial antibody-based assays for the diagnosis of acute Chikungunya infection.

Authors
  • Blacksell, Stuart D
  • Tanganuchitcharnchai, Ampai
  • Jarman, Richard G
  • Gibbons, Robert V
  • Paris, Daniel H
  • Bailey, Mark S
  • Day, Nicholas P J
  • Premaratna, Ranjan
  • Lalloo, David G
  • de Silva, H Janaka
Type
Published Article
Journal
Clinical and vaccine immunology : CVI
Publication Date
Oct 01, 2011
Volume
18
Issue
10
Pages
1773–1775
Identifiers
DOI: 10.1128/CVI.05288-11
PMID: 21865416
Source
Medline
License
Unknown

Abstract

A Sri Lankan fever cohort (n = 292 patients; 17.8% prevalence) was used to assess two standard diagnostic Chikungunya IgM tests. The immunochromatographic test (ICT) acute sample sensitivity (SN) was 1.9 to 3.9%, and specificity (SP) was 92.5 to 95.0%. The enzyme-linked immunosorbent assay (ELISA) gave an acute sample SN of 3.9% and an SP of 92.5% and a convalescent sample SN of 84% and an SP of 91%. These assays are not suitable for the acute diagnosis of Chikungunya virus infection.

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