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Pooled nucleic acid testing to detect antiretroviral treatment failure in Mexico.

Authors
  • Tilghman, Myres W
  • Guerena, Don Diego
  • Licea, Alexei
  • Pérez-Santiago, Josué
  • Richman, Douglas D
  • May, Susanne
  • Smith, Davey M
Type
Published Article
Journal
JAIDS Journal of Acquired Immune Deficiency Syndromes
Publisher
Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins
Publication Date
Mar 01, 2011
Volume
56
Issue
3
Identifiers
DOI: 10.1097/QAI.0b013e3181ff63d7
PMID: 21124228
Source
Medline
License
Unknown

Abstract

Despite limited clinical data, high prevalence of detectable viral loads and a contaminated matrix, pooling greatly improved efficiency of virologic monitoring while maintaining accuracy. By improving cost-effectiveness, these methods could provide sustainability of virologic monitoring in resource-limited settings, and incorporation of developed QA measures will most likely maximize pooling efficiency in future uses.

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