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A pooled analysis of adjunctive topiramate in refractory partial epilepsy.

Authors
  • Peeters, K
  • Adriaenssen, I
  • Wapenaar, R
  • Neto, W
  • Pledger, G
Type
Published Article
Journal
Acta neurologica Scandinavica
Publication Date
Jul 01, 2003
Volume
108
Issue
1
Pages
9–15
Identifiers
PMID: 12807387
Source
Medline
License
Unknown

Abstract

The efficacy of TPM add-on in partial epilepsy is consistent across efficacy endpoints and independent of study population characteristics. The response at 200 mg TPM is similar to the response at higher doses, but as drop-outs caused by adverse events are more frequent above the 200 mg dose, this pooled analysis supports that 200 mg daily is a good target dose for add-on therapy in most patients with partial epilepsy, showing an excellent balance between efficacy and tolerability.

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