Affordable Access

Access to the full text

Polyunsaturated fatty acids: From diet to binding to ppars and other nuclear receptors

Authors
  • Bordoni, A.1
  • Di Nunzio, M.1
  • Danesi, F.1
  • Biagi, P. L.1
  • 1 University of Bologna Via Irnerio, Centro Ricerche sulla Nutrizione - Department of Biochemistry “G. Moruzzi”, Bologna, 48-40126, Italy , Bologna (Italy)
Type
Published Article
Journal
Genes & Nutrition
Publisher
Springer-Verlag
Publication Date
Jun 01, 2006
Volume
1
Issue
2
Pages
95–106
Identifiers
DOI: 10.1007/BF02829951
Source
Springer Nature
Keywords
License
Yellow

Abstract

Dietary polyunsaturated fatty acids (PUFAs) function not only by altering membrane lipid composition, cellular metabolism, signal transduction, but possess also effects on gene expression by regulating the activity/abundance of different nuclear transcription factors: peroxisome proliferator activated receptors, retinoid X receptors, liver X receptors, hepatic nuclear factors-4a, and sterol regulatory binding proteins 1 and 2. PUFAs regulate the expression of genes in various tissues, including the liver, heart, adipose tissue, and brain, playing a major role in carbohydrate, fatty acid, triglyceride, and cholesterol metabolism. Before binding to transcription factors, PUFAs must be absorbed in the intestine and delivered to cells, and then they must enter the cell and the nucleus. PUFA concentration within the cell depends on many different factors, and regulate their possibility to act as transcription modulators. The aim of this review is to summarize recent knowledge about PUFAs destiny from dietto nuclear factors binding, examining the different variables which can modulate their interaction with nuclear factors themselves and therefore their effect on gene expression.

Report this publication

Statistics

Seen <100 times