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Transcriptional control of RfaH on polysialic and colanic acid synthesis by Escherichia coli K92

Authors
  • Navasa, Nicolás
  • Rodríguez-Aparicio, Leandro B.
  • Ferrero, Miguel Ángel
  • Monteagudo-Mera, Andrea
  • Martínez-Blanco, Honorina1, 2, 3
  • 1 Departamento de Biología Molecular
  • 2 Área de Bioquímica y Biología Molecular
  • 3 Universidad de León
Type
Published Article
Journal
FEBS Letters
Publisher
Wiley (John Wiley & Sons)
Publication Date
Jan 01, 2014
Accepted Date
Jan 13, 2014
Volume
588
Issue
6
Pages
922–928
Identifiers
DOI: 10.1016/j.febslet.2014.01.047
Source
Elsevier
Keywords
License
Unknown

Abstract

The transcriptional antiterminator RfaH promotes transcription of long operons encoding surface cell components important for the virulence of Escherichiacoli pathogens. In this paper, we show that RfaH enhanced kps expression for the synthesis of group 2 polysialic acid capsule in E. coli K92. In addition, we demonstrate for the first time that RfaH promotes cps expression for the synthesis of colanic acid, a cell wall component with apparently no role on pathogenicity. Finally, we show a novel RfaH requirement for growth at low temperatures.

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