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Polyreactive Broadly Neutralizing B cells Are Selected to Provide Defense against Pandemic Threat Influenza Viruses

Authors
  • Guthmiller, Jenna J.1
  • Lan, Linda Yu-Ling2
  • Fernández-Quintero, Monica L.3
  • Han, Julianna4
  • Utset, Henry A.1
  • Bitar, Dalia J.1
  • Hamel, Natalie J.1
  • Stovicek, Olivia1
  • Li, Lei1
  • Tepora, Micah1
  • Henry, Carole1
  • Neu, Karlynn E.1, 2
  • Dugan, Haley L.2
  • Borowska, Marta T.5
  • Chen, Yao-Qing1
  • Liu, Sean T.H.6
  • Stamper, Christopher T.2
  • Zheng, Nai-Ying1
  • Huang, Min1
  • Palm, Anna-Karin E.1
  • And 8 more
  • 1 Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL 60637, USA
  • 2 Committee on Immunology, University of Chicago, Chicago, IL 60637, USA
  • 3 Center for Molecular Biosciences Innsbruck, Institute of General, Inorganic and Theoretical Chemistry, University of Innsbruck, 6020 Innsbruck, Austria
  • 4 Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
  • 5 Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637, USA
  • 6 Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
  • 7 Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
  • 8 Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
  • 9 The Tisch Cancer Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA
  • 10 Department of Microbiology and Immunology and Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Type
Published Article
Journal
Immunity
Publication Date
Dec 15, 2020
Volume
53
Issue
6
Pages
1230–1244
Identifiers
DOI: 10.1016/j.immuni.2020.10.005
PMID: 33096040
PMCID: PMC7772752
Source
PubMed Central
Keywords
Disciplines
  • Article
License
Unknown

Abstract

Polyreactivity is a common feature of antibodies, but little is known about the selection, function, and role of polyreactive B cells against pathogens. Guthmiller et al. demonstrate polyreactive B cells are selected against broadly neutralizing epitopes of influenza viruses and are linked to increased viral-binding breadth, affinity, and antibody flexibility.

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