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Polyphyletic origins of bacterial Nramp transporters.

Authors
  • Cellier, M F
  • Bergevin, I
  • Boyer, E
  • Richer, E
Type
Published Article
Journal
Trends in Genetics
Publisher
Elsevier
Publication Date
Jul 01, 2001
Volume
17
Issue
7
Pages
365–370
Identifiers
PMID: 11418195
Source
Medline
License
Unknown

Abstract

The redox-active metals iron and manganese are required for energy metabolism, protection against oxidative stress and defense against infections. In eukaryotes, both divalent metals are transported by Nramp transporters. The sequence of these transporters was remarkably conserved during evolution. Several bacterial Nramp homologs (MntH) are also proton-dependent manganese transporters. Here, we present phylogenetic evidence for the polyphyletic origins of three groups of MntH proteins and for possible Nramp horizontal gene transfer with eukaryotes. We propose that the evolution of the MntH/Nramp family is related to adaptation to oxidative environments, including those arising during infection of animals and plants.

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