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The polyol domain of amphidinol 3. A stereoselective synthesis of the entire C(1)-C(30) sector.

Authors
  • Paquette, Leo A
  • Chang, Shuh-Kuen
Type
Published Article
Journal
Organic Letters
Publisher
American Chemical Society
Publication Date
Jul 07, 2005
Volume
7
Issue
14
Pages
3111–3114
Identifiers
PMID: 15987218
Source
Medline
License
Unknown

Abstract

[structure: see text] The richly oxygenated C(1)-C(30) polyol segment of amphidinol 3 has been synthesized in protected form. Incorporated in this long chain are 10 of the 25 stereogenic centers housed in the target. The asymmetric pathway that has been developed is based on the efficient union of three independently prepared subunits.

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