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Polymorphous low-grade adenocarcinoma of submandibular gland origin.

Authors
  • Haba, R
  • Kobayashi, S
  • Miki, H
  • Hirakawa, E
  • Saoo, K
  • Iwai, T
  • Mori, S
  • Ohmori, M
Type
Published Article
Journal
Acta pathologica japonica
Publication Date
Dec 01, 1993
Volume
43
Issue
12
Pages
774–778
Identifiers
PMID: 8109255
Source
Medline
License
Unknown

Abstract

A case of polymorphous low-grade adenocarcinoma (PLGA) in the submandibular gland is reported. A 72 year old woman presented with a 5 year history of a gradually expanding tumor in the submandibular region. The surgical specimen revealed a relatively well demarcated tumor, 35 x 35 x 20 mm in size. Macroscopically, necrosis and hemorrhage were not seen in the solid tumor. Histologically, the tumor growth pattern was variable, composed of tubular, papillary, solid, trabecular and cribriform structures. Immunohistochemically, some tumor cells were positive for epithelial membrane antigen (EMA), S-100 protein, keratin, and carcinoembryonic antigen (CEA). Electron microscopically, prominent microvilli projected into the luminal spaces, and basal lamina and hemidesmosomes were seen in the tumor cells adjacent to the connective tissues. The submandibular gland is an extremely rare location for PLGA. To the authors' knowledge, this is the first case of its kind reported in the English literature.

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