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Polymorphisms in oxidative stress-related genes are associated with nasopharyngeal carcinoma susceptibility.

Authors
  • Guemira, Fethi
  • Ryad Tamouza
  • Ben Chaaben, Arij
  • Mariaselvam, Christina
  • Salah, Sofiane
  • Busson, Marc
  • Dulphy, Nicolas
  • Douik, Hayet
  • Ghanem, Abderraouf
  • Boukaouci, Wahid
  • Al Daccak, Reem
  • Mamoghli, Tesnim
  • Harzallah, Latifa
  • Bouassida, Jihene
  • Fortier, Catherine
  • Gritli, Said
  • Ben Hamida, Jeannette
  • Charron, Dominique
  • Krishnamoorthy, Rajagopal
Type
Published Article
Journal
Trends in Molecular Medicine
Publisher
Elsevier
Publication Date
January 2015
Volume
220
Issue
1
Pages
20–25
Identifiers
PMID: 25446398
Source
USPC - SET - SVS
License
Unknown

Abstract

Nasopharyngeal carcinoma (NPC) is a complex multifactorial disorder involving both genetic and environmental factors. Polymorphisms of genes encoding nitric oxide synthase (NOS) and antioxidant glutathione-S transferases (GSTs) have been associated with various tumors. We examined the combined role of NOS3, NOS2 and GST polymorphisms in NPC risk in Tunisians. We found that NOS3−786C allele and −786 CC genotype, NOS3+894T allele and +894 GT+TT genotypes, NOS2−277 G allele and −277 GG genotype, and GSTT1 del/del genotype, are more prevalent in NPC patients as compared to healthy controls. Our results suggest that genetically driven dysfunction in red–ox stress pathway could augment the risk in NPC-susceptible individuals.

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