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Polymorphisms in the Apolipoprotein L1 gene and their effects on blood lipid and glucose levels in middle age males

Authors
  • Page, Nigel M.1
  • Olano-Martin, Estibaliz2
  • Lanaway, Christopher1
  • Turner, Rufus2
  • Minihane, Anne Marie2
  • 1 The University of Reading, School of Biological Sciences, Reading, RG6 6AJ, UK , Reading (United Kingdom)
  • 2 The University of Reading, The Hugh Sinclair Unit of Nutrition, RG6 6AP, UK , RG6 6AP (United Kingdom)
Type
Published Article
Journal
Genes & Nutrition
Publisher
Springer-Verlag
Publication Date
Jun 01, 2006
Volume
1
Issue
2
Pages
133–135
Identifiers
DOI: 10.1007/BF02829955
Source
Springer Nature
Keywords
License
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Abstract

Apolipoprotein L1 in plasma is associated with high-density lipoprotein. Novel APOL1 polymorphisms are investigated along with the association of two common haplotypes (Lysl66Glu, Ile244Met, Lys271Arg) with circulating lipid and glucose levels. Although the amino acid substitutions occur in the amphipathic alpha helices region involved in lipid binding, these substitutions were found not to independently account for variability in circulating lipid and glucose levels in 149 middle age males.

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