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Polymorphisms in adiposity-related genes are associated with age at menarche and menopause in breast cancer patients and healthy women.

Authors
  • Kim, Kyee-Zu
  • Shin, Aesun
  • Lee, Yeon-Su
  • Kim, Sook-Young
  • Kim, Yeonju
  • Lee, Eun-Sook
Type
Published Article
Journal
Human Reproduction
Publisher
Oxford University Press
Publication Date
Jul 01, 2012
Volume
27
Issue
7
Pages
2193–2200
Identifiers
DOI: 10.1093/humrep/des147
PMID: 22537818
Source
Medline
License
Unknown

Abstract

Four SNPs (rs2167270 of LEP, rs7602 of LEPR and rs4684846 and rs3856806 of PPARγ) were associated with late menarche (≥ 17-year-old). Four SNPs (rs2167270 of LEP and rs1801282, rs2120825, and rs3856806 of PPARγ) were associated with early menopause (<40-year-old) among post-menopausal women. In logistic regression models with covariate adjustment, women with the GG genotype of rs7602 (LEPR) had a higher risk for late menarche [odds ratio (OR) = 1.83, 95% confidence interval (CI) = 1.01-3.31] compared with their counterparts carrying the GA or AA genotypes. In addition, the GG genotype of rs2167270 (LEP) was inversely associated with a duration of menstruation of <30 years (OR = 0.59, 95% CI = 0.31-1.00) compared with the GA or AA genotypes. BIAS, LIMITATIONS AND GENERALIZABILITY TO OTHER POPULATIONS: We obtained information on the age at menarche and menopause from self-administered questionnaires, and some participants might have had difficulty in remembering their age at menarche and menopause. However, this is a non-differential misclassification and should not appreciably affect the interpretation of the results of this study.

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