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Polymorphism of DCDC2 Reveals Differences in Cortical Morphology of Healthy Individuals—A Preliminary Voxel Based Morphometry Study

Authors
  • Meda, Shashwath A.1
  • Gelernter, Joel2, 3, 4
  • Gruen, Jeffrey R.5, 6
  • Calhoun, Vince D.1, 2, 7, 8
  • Meng, Haiying6
  • Cope, Natalie A.6
  • Pearlson, Godfrey D.1, 2
  • 1 Institute of Living at Hartford Hospital, Olin Neuropsychiatry Research Center, 200 Retreat Ave., Hartford, CT, 06106, USA , Hartford (United States)
  • 2 Yale University School of Medicine, Department of Psychiatry, New Haven, CT, USA , New Haven (United States)
  • 3 Yale University School of Medicine, Department Neurobiology, New Haven, CT, USA , New Haven (United States)
  • 4 VA CT Healthcare Center, West Haven, CT, USA , West Haven (United States)
  • 5 Yale University School of Medicine, Department of Genetics, New Haven, CT, USA , New Haven (United States)
  • 6 Yale University School of Medicine, Department of Pediatrics, Yale Child Health Research Center, New Haven, CT, USA , New Haven (United States)
  • 7 The MIND Institute, Albuquerque, NM, USA , Albuquerque (United States)
  • 8 University of New Mexico, Department of ECE, Albuquerque, NM, USA , Albuquerque (United States)
Type
Published Article
Journal
Brain Imaging and Behavior
Publisher
Springer-Verlag
Publication Date
Nov 27, 2007
Volume
2
Issue
1
Pages
21–26
Identifiers
DOI: 10.1007/s11682-007-9012-1
Source
Springer Nature
Keywords
License
Yellow

Abstract

ObjectiveThe purpose of this investigation was to determine whether there is an association between the putative reading disability (RD) susceptibility gene Doublecortin Domain Containing 2 (DCDC2), and gray matter (GM) distribution in the brain, in a sample of healthy control individuals.MethodFifty-six control subjects were genotyped for an RD-associated deletion in intron 2 of DCDC2. Voxel based morphometry (VBM) was used to examine structural magnetic resonance imaging (MRI) scans to assess GM differences between the two groups.ResultsIndividuals heterozygous for the deletion exhibited significantly higher GM volumes in reading/language and symbol-decoding related brain regions including superior, medial and inferior temporal, fusiform, hippocampal/parahippocampal, inferior occipito-parietal, inferior and middle frontal gyri, especially in the left hemisphere. GM values correlated with published data on regional DCDC2 expression in a lateralized manner.ConclusionsThese data suggest a role for DCDC2 in GM distribution in language-related brain regions in healthy individuals.

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