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A polymorphism in the CTGF promoter region associated with systemic sclerosis.

Authors
  • Fonseca, Carmen
  • Lindahl, Gisela E
  • Ponticos, Markella
  • Sestini, Piersante
  • Renzoni, Elisabetta A
  • Holmes, Alan M
  • Spagnolo, Paolo
  • Pantelidis, Panagiotis
  • Leoni, Patricia
  • McHugh, Neil
  • Stock, Carmel J
  • Shi-Wen, Xu
  • Denton, Christopher P
  • Black, Carol M
  • Welsh, Kenneth I
  • du Bois, Roland M
  • Abraham, David J
Type
Published Article
Journal
New England Journal of Medicine
Publisher
New England Journal of Medicine
Publication Date
Sep 20, 2007
Volume
357
Issue
12
Pages
1210–1220
Identifiers
PMID: 17881752
Source
Medline
License
Unknown

Abstract

The G-945C substitution represses CTGF transcription, and the -945G allele is significantly associated with susceptibility to systemic sclerosis.

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