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A polymethoxyflavone mixture extracted from orange peels, mainly containing nobiletin, 3,3',4',5,6,7,8-heptamethoxyflavone and tangeretin, suppresses melanogenesis through the acidification of cell organelles, including melanosomes.

Authors
  • Yoshizaki, Norihiro1
  • Hashizume, Ron2
  • Masaki, Hitoshi3
  • 1 Advanced Technology Research Laboratory, NOF Corporation, 5-10 Tokodai, Tsukuba, Ibaraki 300-2635, Japan. Electronic address: [email protected] , (Japan)
  • 2 Advanced Technology Research Laboratory, NOF Corporation, 5-10 Tokodai, Tsukuba, Ibaraki 300-2635, Japan. , (Japan)
  • 3 School of Bioscience and Biotechnology, Tokyo University of Technology, 1404-1, Katakura-machi, Hachioji-shi, Tokyo 192-0982, Japan. , (Japan)
Type
Published Article
Journal
Journal of dermatological science
Publication Date
Oct 01, 2017
Volume
88
Issue
1
Pages
78–84
Identifiers
DOI: 10.1016/j.jdermsci.2017.06.008
PMID: 28629701
Source
Medline
Keywords
License
Unknown

Abstract

These results suggest that the PMF mixture suppresses the localization of tyrosinase to melanosomes and consequently inhibits melanogenesis due to the acidification of cell organelles, including melanosomes.

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