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A polymeric nanoparticle consisting of mPEG-PLA-Toco and PLMA-COONa as a drug carrier: improvements in cellular uptake and biodistribution.

Authors
  • Yi, Yilwoong
  • Kim, Jae Hong
  • Kang, Hye-Won
  • Oh, Hun Seung
  • Kim, Sung Wan
  • Seo, Min Hyo
Type
Published Article
Journal
Pharmaceutical research
Publication Date
Feb 01, 2005
Volume
22
Issue
2
Pages
200–208
Identifiers
PMID: 15783067
Source
Medline
License
Unknown

Abstract

Dox-PNP exhibited enhanced cellular uptake of the drug. In the cytotoxic activity study, this improved cellular uptake was proved to be more advantageous in drug-resistant cell. Dox-PNP exhibited much higher bioavailability in blood plasma and more drug accumulation in tumor tissue than conventional doxorubicin formulation. The results of this study suggest that the PNP system is an advantageous carrier for drug delivery.

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