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Polymeric nanocarriers for the treatment of systemic iron overload

Authors
  • Hamilton, Jasmine L1
  • Kizhakkedathu, Jayachandran N1, 2
  • 1 The Centre for Blood Research, Department of Pathology and Laboratory Medicine, Vancouver, BC, V6T 1Z3, Canada , Vancouver (Canada)
  • 2 University of British Columbia, Department of Chemistry, 2350 Health Sciences Mall, Vancouver, BC, V6T 1Z3, Canada , Vancouver (Canada)
Type
Published Article
Journal
Molecular and Cellular Therapies
Publisher
"ClinTransMed, AB"
Publication Date
Mar 24, 2015
Volume
3
Issue
1
Identifiers
DOI: 10.1186/s40591-015-0039-1
Source
Springer Nature
Keywords
License
Green

Abstract

Desferrioxamine (DFO), deferiprone (L1) and desferasirox (ICL-670) are clinically approved iron chelators used to treat secondary iron overload. Although iron chelators have been utilized since the 1960s and there has been much improvement in available therapy, there is still the need for new drug candidates due to limited long-term efficacy and drug toxicity. Moreover, all currently approved iron chelators are of low molecular weight (MW) (<600 Da) and the objectives reported for the “ideal” chelator of low MW, including possessing the ability to promote iron excretion without causing toxic side effects, has proven difficult to realize in practice. With prolonged iron chelator use, patients may develop toxicities or become insensitive. In contrast, the limited research that has been geared towards developing higher MW, polymeric, long circulating iron chelators has shown promise. The inherent potential of polymeric iron chelators toward longer plasma half-lives and reduction in toxicity provides optimism and may be a significant addition to the currently available low MW iron chelators. This article reviews knowledge pertaining to this theme, highlights some unique advantages that these nanomedicines have in treating systemic iron overload as well as their potential utility in the treatment of other disease states.

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