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Polymer Nanoliter Well Arrays for Liquid Storage and Rapid On-demand Electrochemical Release

Authors
  • Vastesson, Alexander
  • Guo, Maoxiang
  • Haraldsson, Tommy
  • van der Wijngaart, Wouter
Publication Date
Jan 01, 2018
Identifiers
DOI: 10.1016/j.snb.2018.04.013
OAI: oai:DiVA.org:kth-215017
Source
DiVA - Academic Archive On-line
Keywords
Language
English
License
Green
External links

Abstract

Polymer microfluidic systems are of increasing importance in several applications in biomedicine and biosensing. The integrated encapsulation, storage, and controlled release of small amounts of liquid in such systems remains an unresolved technical challenge. Here, we report two methods for the room-temperature and adhesive-free sealing of 1–330 nanoliter volumes of liquid in off-stoichiometry thiol-ene polymer well arrays by spontaneous bonding to 200 nm thin gold films. Sealed well arrays were stored for more than one month in a liquid environment with <10% liquid loss, and for more than one week in air with minimal loss. We demonstrated that controlling the electrical potential and polarity over encapsulated wells allowed for selecting one of two well opening mechanisms: slow anodic electrochemical etching, or rapid electrolytic gas pressure-induced bursting of the gold film. The results may find potential applications in diagnostic testing, in vivo drug delivery, or in spatio-temporal release of chemical compounds in biological assays. / <p>QC 20180515</p>

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