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Polyketides from marine dinoflagellates of the genus Prorocentrum, biosynthetic origin and bioactivity of their okadaic acid analogues.

Authors
  • Hu, Weimin
  • Xu, Jing
  • Sinkkonen, Jari
  • Wu, Jun
Type
Published Article
Journal
Mini reviews in medicinal chemistry
Publication Date
Jan 01, 2010
Volume
10
Issue
1
Pages
51–61
Identifiers
PMID: 20105116
Source
Medline
License
Unknown

Abstract

Marine dinoflagellates of the genus Prorocentrum are famous for the production of okadaic acid (OA) and its analogues. This review covers first the source, chemistry and bioactivity of polyketides from Prorocentrum species. Then recent advances in the studies of biosynthetic origin of OA and its analogues are included. Moreover, the pharmacophore for the selective inhibition of OA to protein phosphatases types 1 (PP1) and 2A (PP2A) is highlighted.

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