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Polycystic ovary syndrome and related inflammation in radiomics; relationship with patient outcome.

Authors
  • Zheng, Chun-Yang1
  • Yu, Yue-Xin2
  • Bai, Xue3
  • 1 Embryo Laboratory, Jinghua Hospital of Shenyang, No. 83, Zhongshan Road, Heping District, Shenyang 110000, Liaoning Province, China. , (China)
  • 2 Department of Reproductive Medicine, General Hospital of Northern Theater Command, No. 5, Guangrong Street, Heping District, Shenyang 110000, Liaoning Province, China. , (China)
  • 3 Department of Reproductive Medicine, General Hospital of Northern Theater Command, No. 5, Guangrong Street, Heping District, Shenyang 110000, Liaoning Province, China. Electronic address: [email protected]. , (China)
Type
Published Article
Journal
Seminars in Cell and Developmental Biology
Publisher
Elsevier
Publication Date
Feb 15, 2024
Volume
154
Issue
Pt C
Pages
328–333
Identifiers
DOI: 10.1016/j.semcdb.2023.02.013
PMID: 36933953
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Polycystic ovary syndrome (PCOS) refers to a condition that often has 'poly' liquid containing sacks around ovaries. It affects reproductive-aged females giving rise to menstrual and related reproductive issues. PCOS is marked by hormonal imbalance often resulting in hyperandrogenism. Inflammation is now considered a central manifestation of this disease with several inflammatory biomarkers such as TNF-α, C-reactive protein and Interleukins-6/18 found to be particularly elevated in PCOS patients. Diagnosis is often late, and MRI-based diagnosis, along with blood-based analyses, are still the best bet for a definitive diagnosis. Radiomics also offers several advantages and should be exploited to the maximum. The mechanisms of PCOS onset and progression are not very well known but pituitary dysfunction and elevated gonadotrophin releasing hormone resulting in high levels of luteinizing hormone are indicative of an activated hypothalamic-pituitary-ovarian axis in PCOS. A number of studies have also identified signaling pathways such as PI3K/Akt, NF-κB and STAT in PCOS etiology. The links of these signaling pathways to inflammation further underline the importance of inflammation in PCOS, which needs to be resolved for improving patient outcomes. Copyright © 2023 Elsevier Ltd. All rights reserved.

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