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Polybrominated Diphenyl Ethers, Polybrominated Biphenyls, and Risk of Papillary Thyroid Cancer: A Nested Case-Control Study

Authors
  • Huang, Huang1
  • Sjodin, Andreas2
  • Chen, Yingtai3, 4, 5
  • Ni, Xin6
  • Ma, Shuangge7
  • Yu, Herbert8
  • Ward, Mary H9
  • Udelsman, Robert10
  • Rusiecki, Jennifer11
  • Zhang, Yawei1, 3, 4
  • 1 Department of Environmental Health Sciences
  • 2 Persistent Pollutants Biomonitoring Laboratory, Georgia , (Georgia)
  • 3 Department of Surgery
  • 4 Yale Cancer Center
  • 5 Cancer Institute and Hospital, China , (China)
  • 6 Beijing Children’s Hospital, China , (China)
  • 7 Department of Biostatistics
  • 8 Epidemiology Program
  • 9 Occupational and Environmental Epidemiology Branch
  • 10 Endocrine Neoplasia Institute
  • 11 and Uniformed Services University of the Health Sciences
Type
Published Article
Journal
American Journal of Epidemiology
Publisher
Oxford University Press
Publication Date
Nov 19, 2019
Volume
189
Issue
2
Pages
120–132
Identifiers
DOI: 10.1093/aje/kwz229
PMID: 31742588
PMCID: PMC7156139
Source
PubMed Central
Keywords
License
Unknown

Abstract

A nested case-control study was carried out using data from the US Department of Defense cohort between 2000 and 2013 to investigate the associations of papillary thyroid cancer (PTC) with serum concentrations of polybrominated diphenyl ethers and polybrominated biphenyls. This study included 742 histologically confirmed PTC cases (in 341 women and 401 men) and 742 matched controls with prediagnostic serum samples from the Department of Defense Serum Repository. Lipid-corrected serum concentrations of 8 congeners were measured. Multivariate conditional logistic regression analyses were performed for classical PTC and follicular variant of PTC, respectively. We also examined effect modification by sex. BDE-28, a polybrominated diphenyl ether congener, was associated with significantly increased risk of classical PTC (for the third tertile vs. below the limit of detection, odds ratio = 2.09, 95% confidence interval: 1.05, 4.15; P for trend = 0.02), adjusting for other congeners, body mass index, and branch of military service. This association was observed mainly for larger classical PTC (tumor size > 10 mm), with a significantly stronger association among women than men ( P for interaction = 0.004). No consistent associations were observed for other congeners, including those at higher concentrations. This study found a significantly increased risk of classical PTC associated with increasing levels of BDE-28. The risk varied by sex and tumor size.

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