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Poly(aspartic acid) based self-healing hydrogels with antibacterial and light-emitting properties for wound repair.

Authors
  • Shen, Jiafu1
  • Zhou, Ziwei2
  • Chen, Danyang1
  • Wang, Yong3
  • He, Yingna4
  • Wang, Dong5
  • Qin, Jianglei6
  • 1 College of Chemistry and Environmental Science, Hebei University, Baoding, Hebei Province, 071002, PR China. , (China)
  • 2 Hebei Key Laboratory of Chinese Medicine Research on Cardio-Cerebrovascular Disease, Pharmaceutical College, Hebei University of Chinese Medicine, Shijiazhuang, Hebei Province, 050200, PR China. , (China)
  • 3 Medical College, Hebei University, Baoding, Hebei Province, 071002, PR China. , (China)
  • 4 Hebei Key Laboratory of Chinese Medicine Research on Cardio-Cerebrovascular Disease, Pharmaceutical College, Hebei University of Chinese Medicine, Shijiazhuang, Hebei Province, 050200, PR China; Hebei Higher Education Institute Applied Technology Research Center on TCM Formula Preparation, Shijiazhuang, 050091, PR China. Electronic address: [email protected] , (China)
  • 5 State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing, 100029, PR China. Electronic address: [email protected] , (China)
  • 6 College of Chemistry and Environmental Science, Hebei University, Baoding, Hebei Province, 071002, PR China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Colloids and surfaces. B, Biointerfaces
Publication Date
Jan 11, 2021
Volume
200
Pages
111568–111568
Identifiers
DOI: 10.1016/j.colsurfb.2021.111568
PMID: 33460966
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

We report here a self-healing hydrogel with antibacterial and light-emitting properties for wound repair. The hydrogel was prepared by reaction of poly(aspartic acid) (PASP) derivatives bearing groups of quaternary ammonium and boronic acid with poly(vinyl alcohol) (PVA). Due to the dynamic nature of boronic ester bonds, bacteria-killing activity of quaternary ammonium, and light-emitting activity of phenylboronic ester, the resultant hydrogels featured self-healing, antibacterial and light-emitting properties. The hydrogels show controlled release behavior of mouse epidermal growth factor (mEGF) and the in vivo studies show mEGF loaded hydrogel accelerate the wound repair of model mice and improve skin cell proliferation by prevention of bacterial infections. The PASP based hydrogels would show great promise in bio-applications, in particular for wound dressing and tissue repairing. Copyright © 2021. Published by Elsevier B.V.

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